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KMID : 1020120060040010049
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Journal of the Korean Academy of Clinical Electrophysiology
2006 Volume.4 No. 1 p.49 ~ p.61
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Skin Permeation Effects of Meloxicam Gel on Ultrasound Parameters by Phonophoresis
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Choi Sug-Ju
Yoon Se-Won
Jeong Dae-In
Kim Young-Il
Jung Jin-Gyu
Kim Tae-Youl
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Abstract
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This study conducted the following experiment to examine and compare transdermal permeation effects according to parameters of ultrasound and physiochemical characteristics of meloxicam. Permeation by ultrasound among these experimental drugs was relatively higher and it was involved in COX-2 inhibition unlike other drugs. Recently use of oral agents has been rapidly increased, but it was not generalized to transdermal agent and this study selected meloxicam that transdermal permeation research using ultrasound was not performed and conducted transdermal permeation experiment with skin of hairless mouse and analyzed permeation with HPLC. It made gel first and analyzed permeation depending on frequency and intensity of ultrasound of meloxicam with the same experimental procedures as the above experiment. The results of this study can be summarized as follows. Transdermal permeation by ultrasound frequency was higher in 1.0 MHz and it was higher as intensity increased. In comparison by parameters of ultrasound, there was similar permeation in of continuous mode and of pulsed mode and it was effective to high intensity for using pulsed mode. It was found that duty cycle of ultrasound affected transdermal permeation in meloxicam gel used in this experiment and transdermal permeation was higher in used ultrasound as phonophoresis than non-ultrasound for anti-inflammatory effects.
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KEYWORD
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Meloxicam, Phonophoresis, Transdermal drug delivery, Ultrasound
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